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KMID : 0363220080460060821
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Korean Journal of Dermatology
2008 Volume.46 No. 6 p.821 ~ p.825
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Two Cases of Anti-p200 Pemphigoid
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Kim Mi-Ri
Jang Jae-Yong
Kim Soo-Chan
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Abstract
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Anti-p200 pemphigoid is a recently defined subepidermal immunobullous disease. Most anti-p200 pemphigoid patients show the clinical features of bullous pemphigoid, dermatitis herpetiformis and linear IgA disease. It is characterized by the binding of circulating IgG autoantibodies to the dermal side of 1 M NaCl split skin, and by reactivity of these autoantibodies to a unique 200-kD antigen on immunoblot of dermal extract. On immunoelectron microscopic examination, these autoantibodies deposit at the lamina lucida-lamina densa interface. Herein, we report two cases of anti-p200 pemphigoid, as well as their favorable response to treatment with systemic corticosteroid, colchicine and dapsone. (Korean J Dermatol 2008;46(6):821∼825
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KEYWORD
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Anti-p200 pemphigoid, Immunoblot, 200-kDa antigen
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